In a study published in the Journal of the American Medical Association, 240 milligrams per day of the dietary supplement Ginkgo biloba was found to be ineffective in reducing the development of dementia and Alzheimer's disease in older people. Researchers led by Steven T. DeKosky, M.D., conducted the trial known as the Ginkgo Evaluation of Memory (GEM) study at four clinical sites over the course of 8 years. GEM is the largest clinical trial ever to evaluate ginkgo's effect on the occurrence of dementia.

• Press Release—summary of results of the study


• Questions and Answers—detailed background information on the study

People with advanced cancer often experience pain that causes physical and emotional distress, which leads to a decrease in functional ability and quality of life. Symptom relief is an important part of end-of-life care, and small studies have suggested that massage therapy may benefit people with advanced cancer.

In a study funded in part by NCCAM, researchers investigated the benefits of massage versus simple touch therapy (placing both hands on specific body sites) in patients with advanced cancer. This multisite study—conducted at 15 U.S. hospices in the Population-based Palliative Care Research Network—included 380 participants with advanced cancer who were experiencing moderate-to-severe pain. Participants were randomly assigned to receive six 30-minute treatment sessions of either massage or simple touch therapy over a 2-week period.

Hepatitis C, a liver disease caused by a virus, is usually chronic (long-lasting), with symptoms ranging from mild (or even none) to severe. Conventional medical treatments are available for hepatitis C; however, some people also try complementary and alternative medicine (CAM) therapies, especially herbal supplements. This fact sheet provides basic information on hepatitis C, summarizes scientific research on the effectiveness and safety of selected supplements, and suggests sources for additional information.

Key Points

• No CAM treatment has yet been proven effective for treating hepatitis C or its complications.


• It is important not to replace conventional medical therapy for hepatitis C with an unproven CAM therapy.


• Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

There are 23.6 million adults and children in the United States living with diabetes. Conventional medical treatments are available to control diabetes and its complications. However, some people also try complementary and alternative medicine (CAM) therapies, including dietary supplements. An individual considering using CAM therapy, should talk to their health care providers to ensure safe and coordinated care.

What is Diabetes?

Diabetes is a disease in which the body does not produce or properly use insulin. Insulin is a hormone that is needed to convert sugar, starches and other food into energy needed for daily life. The cause of diabetes continues to be a mystery, although both genetics and environmental factors such as obesity and lack of exercise appear to play roles.

Previous animal studies have indicated that an extract from leaves of the Ginkgo biloba tree may protect against stroke-related brain injury. However, the mechanism involved has not been fully understood. In a recent NCCAM-funded study, researchers at Johns Hopkins University investigated whether and how the ginkgo extract Egb761 alters outcomes in mice with brain injury from stroke.

Treating patients with placebos has a long, complicated, and often controversial history. Nonetheless, little is actually known about U.S. physicians' current attitudes toward and use of placebo treatments. A recent national survey of 679 physicians, funded in part by NCCAM, found that about half the physician respondents prescribed placebo treatments on a regular basis. Most (62%) said they think the practice is ethical. The surveyed physicians were internists and rheumatologists—specialties that commonly treat patients with debilitating chronic conditions.

Initial, independent review of study data from the Selenium and Vitamin E Cancer Prevention Trial (SELECT), funded by the National Cancer Institute (NCI) and other institutes that comprise the National Institutes of Health shows that selenium and vitamin E supplements, taken either alone or together, did not prevent prostate cancer. The data also showed two concerning trends: a small but not statistically significant increase in the number of prostate cancer cases among the over 35,000 men age 50 and older in the trial taking only vitamin E and a small, but not statistically significant increase in the number of cases of adult onset diabetes in men taking only selenium. Because this is an early analysis of the data from the study, neither of these findings proves an increased risk from the supplements and both may be due to chance.

Hot flashes are a problem for many menopausal women and a common side effect of breast cancer treatment. For many breast cancer survivors, vasomotor symptoms result in discomfort, disrupted sleep, anxiety, and decreased quality of life. Hormonal (estrogen) drugs have been used to treat hot flashes, but because estrogens are associated with an increased risk of breast cancer, they usually are avoided by breast cancer survivors. Since nonhormonal treatments do not work for some women and may have adverse effects, new interventions for hot flashes are needed. Previous research has indicated that hypnosis may be a promising alternative.

Chiropractic is a health care approach that focuses on the relationship between the body's structure—mainly the spine—and its functioning. Although practitioners may use a variety of treatment approaches, they primarily perform adjustments to the spine or other parts of the body with the goal of correcting alignment problems and supporting the body's natural ability to heal itself.

The National Institutes of Health's National Center for Complementary and Alternative Medicine (NCCAM) has added four new Centers of Excellence for Research on Complementary and Alternative Medicine (CERCs) to its research centers program. The new centers will add to knowledge about complementary and alternative medicine (CAM) approaches and their potential in treating and preventing diseases and conditions that are common among Americans.

In NCCAM's CERC program, highly accomplished researchers across a variety of disciplines apply cutting-edge technology to projects in CAM.